Training & movement
ANon-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies
Garcia L, Pearce M, Abbas A, Mok A, Strain T, Ali S, Crippa A, Dempsey PC, Golubic R, Kelly P, Laird Y, McNamara E, Moore S, de Sa TH, Smith AD, Wijndaele K, Woodcock J, Brage S · 2023 · British Journal of Sports Medicine
REZA evidence rating A: High confidence
Methodology
Meta-analysis
Population
196 articles covering 94 cohorts with >30 million adults from the general population
Intervention
Non-occupational physical activity (exposure), analysed in marginal MET-hours/week
Findings
More non-occupational physical activity is associated with lower mortality, cardiovascular disease and cancer risk, in a non-linear dose-response relationship. At roughly 150 min/week of moderate activity, all-cause mortality risk is already 31% lower; most benefit accrues in the low-to-moderate range, flattening above ~17.5 mMET-h/week.
Outcome measures
All-cause mortality; incident total CVD, coronary heart disease, stroke, heart failure; total and site-specific cancers
Limitations
Observational data: residual confounding, reverse causation, self-reported activity in most cohorts; heterogeneity in exposure assessment.
Original source
DOI: 10.1136/bjsports-2022-105669 · PMID: 36854652
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