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Training & movement

A

Cardiorespiratory fitness and mortality from all causes, cardiovascular disease and cancer: dose-response meta-analysis of cohort studies

Han M, Qie R, Shi X, Yang Y, Lu J, Hu F, Zhang M, Zhang Z, Hu D, Zhao Y · 2022 · British Journal of Sports Medicine

REZA evidence rating A: High confidence

Methodology

Meta-analysis

Population

34 cohort studies of generally healthy populations (searched to December 2019)

Intervention

Exposure: CRF from exercise stress testing, categorical levels and per 1-MET increment

Findings

Each additional MET of cardiorespiratory fitness was associated with 12% lower all-cause mortality, 13% lower cardiovascular mortality and 7% lower cancer mortality. Even intermediate fitness levels already showed large risk reductions versus low fitness.

Outcome measures

All-cause, cardiovascular and cancer mortality

Limitations

Observational; participant totals not stated in the record; single baseline fitness measurement; possible publication bias and residual confounding.

Original source

DOI: 10.1136/bjsports-2021-104876 · PMID: 35022163

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