Training & movement
ACardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis
Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H · 2009 · JAMA
REZA evidence rating A: High confidence
Methodology
Meta-analysis
Population
33 cohort studies; 102,980 participants/6910 events (all-cause mortality) and 84,323 participants/4485 events (CHD/CVD)
Intervention
Exposure: maximal aerobic capacity in METs (low <7.9, intermediate 7.9-10.8, high ≥10.9)
Findings
Cardiorespiratory fitness is a strong, quantitative predictor of mortality and cardiovascular events: each additional MET was associated with 13% lower mortality risk. Low-fitness individuals had 70% higher mortality risk than high-fitness individuals.
Outcome measures
All-cause mortality; combined coronary heart disease/cardiovascular disease events
Limitations
Observational; searches only to 2008; heterogeneity in fitness testing and adjustment; healthy-cohort restriction limits generalisability to clinical populations.
Original source
DOI: 10.1001/jama.2009.681 · PMID: 19454641
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