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Training & movement
BThe Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis
Burke R, Piñero A, Coleman M, Mohan A, Sapuppo M, Augustin F, Aragon AA, Candow DG, Forbes SC, Swinton P, Schoenfeld BJ · 2023 · Nutrients
REZA evidence rating B: Reasonable confidence
Methodology
Meta-analysis
Population
RCTs of creatine + RT vs placebo + RT; healthy adults
Intervention
Creatine monohydrate + RT vs placebo + RT
Findings
Creatine supplementation produced a small but significant enhancement of regional hypertrophy compared to placebo, with effects consistent across body regions.
Outcome measures
Regional muscle hypertrophy (upper body, lower body measurements)
Limitations
Heterogeneity; varying creatine doses/protocols; mostly untrained; measurement methods varied.
Original source
DOI: 10.3390/nu15092116
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