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Training & movement
AEffects of Calorie Restriction With and Without Strength, Endurance or Mixed Training on Fat-Free and Skeletal Muscle Mass in Overweight or Obese Individuals: A Systematic Review With Pairwise Meta-Analysis and Network Meta-Analysis of Randomized Controlled Studies
Deller M, Weiershaus J, Held S, Brinkmann C · 2026 · Diabetes, Obesity and Metabolism
REZA evidence rating A: High confidence
Methodology
Meta-analysis
Population
Overweight or obese individuals; calorie restriction with and without exercise
Intervention
Calorie restriction alone vs CR + strength training vs CR + endurance vs CR + mixed training
Findings
Adding strength training to calorie restriction better preserved fat-free and skeletal muscle mass compared to calorie restriction alone or calorie restriction plus endurance training. Mixed training was also effective, while endurance alone was less effective for muscle preservation.
Outcome measures
Fat-free mass, skeletal muscle mass
Limitations
Heterogeneity; varying CR protocols; varying exercise protocols.
Original source
DOI: 10.1111/dom.70873 · PMID: 42144246
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