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Training & movement

A

Effects of Calorie Restriction With and Without Strength, Endurance or Mixed Training on Fat-Free and Skeletal Muscle Mass in Overweight or Obese Individuals: A Systematic Review With Pairwise Meta-Analysis and Network Meta-Analysis of Randomized Controlled Studies

Deller M, Weiershaus J, Held S, Brinkmann C · 2026 · Diabetes, Obesity and Metabolism

REZA evidence rating A: High confidence

Methodology

Meta-analysis

Population

Overweight or obese individuals; calorie restriction with and without exercise

Intervention

Calorie restriction alone vs CR + strength training vs CR + endurance vs CR + mixed training

Findings

Adding strength training to calorie restriction better preserved fat-free and skeletal muscle mass compared to calorie restriction alone or calorie restriction plus endurance training. Mixed training was also effective, while endurance alone was less effective for muscle preservation.

Outcome measures

Fat-free mass, skeletal muscle mass

Limitations

Heterogeneity; varying CR protocols; varying exercise protocols.

Original source

DOI: 10.1111/dom.70873 · PMID: 42144246

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